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A B12 deficiency can lead to signs such as fatigue and lowered appetite, and as many as 16% of U.S

Mol Genet Metab 68(2):243257 Roe DS, Vianey-Saban C, Sharma S, Zabot MT, Roe CR (2001) Oxidation of unsaturated fatty acids by human fibroblasts with very-long-chain acyl-CoA dehydrogenase deficiency: aspects of substrate specificity and correlation with clinical phenotype

As the endotheliumthe inner lining of blood vesselsis actively involved in many physiological functions, like controlling blood pressure, blood clotting and signaling during inflammation, endothelial function is crucial for cardiovascular health (62)

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