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The couple applied what they had learned when Herman joined a second clinical trial in July 2022, also at Penn Medicine, this time to receive 17 cycles of an experimental bispecific antibody called cevostamab

Strong arguments in favor of PS exposure being required for microvesicle release come from (1) a bleeding disorder, the Scott syndrome, where RBC neither translocate PS across the membrane nor release microvesicles (Bevers et al., 1992) and (2) the finding that a specific inhibitor of the scramblase (R5421) inhibits both PS exposure and microvesicle release to more than 50% (Gonzalez et al., 2009)

91 GelalisI.GkiatasI.SpiliotisA.PapadopoulosD.PakosE.VekrisM.et al (2019)

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doi: 10.1111/jne.12948 [DOI] [PMC free article] [PubMed] [Google Scholar] 5.Moog NK, Entringer S, Heim C, Wadhwa PD, Kathmann N, Buss C