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Furthermore, studies of IGF-2 gene in transitional cell carcinoma of the bladder and MGMT gene in gastric cancer showed that patients with CT or TT MTHFR genotypes had reduced methylation of IGF-2 or MGMT compared those with CC genotype 36,37

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doi: 10.1016/j.jiec.2017.06.050 114

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The risk of this false positive error is determined entirely by the alpha level, an arbitrary threshold set prior to the study