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The detoxification reactions comprise the first four steps of mercapturic acid synthesis, [19] with the conjugation to GSH serving to make the substrates more soluble and allowing them to be removed from the cell by transporters such as multidrug resistance-associated protein 1 (MRP1)

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10.1126/sciadv.adg2697 58 HaqR.ShoagJ.Andreu-PerezP.YokoyamaS.EdelmanH.RoweG