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doi: 10.1523/JNEUROSCI.3795-08.2008 166 SelmajKWFarooqMNortonWTRaineCSBrosnanCF

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By contrast, increased -KG accelerates the initial differentiation by promoting demethylation reactions that activate lineage-specific genes, but silence pluripotency genes in primed hPSCs and mEpiSCs

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Additionally, the precise spatiotemporal crosstalk between ferroptosis, apoptosis, and necroptosis adds a layer of complexity that confounds the design of specific interventions