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Methods: Data from adults aged 18 and older extrapolated from IBM Explorys Cohort Discovery program was used for this study

Fructose intake on the APAP-metabolizing enzymes and its detoxification The expression levels of CYP2E1 and CYP1A2- the two important enzymes in the formation of the toxic metabolite NAPQI from APAP- were downregulated in mice fed with fructose compared to the levels in mice on a regular chow diet [52]