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For example, ER stress activates DNA damage inducible transcript 3 (DDIT3, also known as CHOP)- and mitogen-activated protein kinase 8 (MAPK8, also known as JNK)-dependent apoptosis pathways, whereas heat shock protein family A member 5 (HSPA5, also known as BIP) SSG at Cys420/441 modulates ATPase activity and protein folding, paradoxically suppressing apoptosis 49

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doi: 10.1371/journal.pone.0021827 277 ToK.CaoR.YegiazaryanA.OwensJ.NguyenT.SasaniniaK.et al

In contrast to these findings, 8 weeks of progressive RT (3 sets of 812 climbs, 50%100% of MCL) on alternating days in aging rats observed increased hippocampal protein expression of TNF- and IL-1 (Vilela et al., 2017)

Excessive production of reactive oxygen species over the power of the antioxidant system as oxidative stress is known to contribute to a variety of diseases like PCOS

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