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Drugs for which a potentially important valproate interaction has been observed Amitriptyline/Nortriptyline Administration of a single oral 50 mg dose of amitriptyline to 15 normal volunteers (10 males and 5 females) who received valproate (500 mg BID) resulted in a 21% decrease in plasma clearance of amitriptyline and a 34% decrease in the net clearance of nortriptyline

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10.1007/s002489900020 [DOI] [PubMed] [Google Scholar] Smyth C., Kalsi G., Curtis D., Brynjolfsson J., O'Neill J., Rifkin L., et al

j , Ogdh expression in intestinal crypts derived from Hnf4/ DKO mice, along with a Venn diagram showing the overlap between HNF4/-dependent genes and SMAD4-dependent genes, derived from published knockout studies