Following extracellular stimulationfor instance, the binding of TNF- to its cell-surface receptora cascade of intracellular signaling events is initiated

Disclosures: Nikia Smith: Nothing to Disclose, Cynthia Moylan: GSK: Grant/Research Support, Madrigal Pharmaceuticals: Grant/Research Support, Exact Sciences: Grant/Research Support, Sirtex: Advisor, NovoNordisk: Consultant, Gina Austin: Nothing to Disclose, Adriana Vidal: Nothing to Disclose, Yukun Liu: Nothing to Disclose, Susan Murphy: Nothing to Disclose, Joellen Schildkraut: Nothing to Disclose, Jeffrey Enders: Nothing to Disclose, Antonio Planchart: Nothing to Disclose, Cathrine Hoyo: Nothing to Disclose 1742 THE OTAGO EXERCISE PROGRAM IMPROVES LIVER FRAILTY IN PRE-TRANSPLANT CANDIDATES Neil Shah 1 Kathryn Bridgens 2 Jyotsna Gupta 1 Deborah Givens 1 , 1 University of North Carolina at Chapel Hill School of Medicine, 2 UNC Health Background: Outpatient pre-habilitation has effectively improved the frailty of candidates for liver transplant (LT)

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