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These functional protective effects are consistent with metaproteomic findings in children with recent-onset T1D (188), where gut microbiota dysregulation (including reduced butyrate-producing taxa) correlates with -cell damage severity, supporting a clinical link between butyrate deficiency and T1D pathogenesis

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Chen H-I, Hu W-S, Hung M-Y, Ou H-C, Huang S-H, Hsu P-T et al (2020) Protective effects of luteolin against oxidative stress and mitochondrial dysfunction in endothelial cells

However, it is commonly observed that the terminal ileal or perianal region is more susceptible to CD, resulting in a discontinuous type of transmural inflammation

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