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however, it has been found that the use of CD38 inhibitors can reverse this effect and restore T cell proliferation ( Relationship Between Targeted CD38 Therapy and Programmed Cell Death 1 (PD-1/PD-1 Ligand 1 (PD-L1) Efficacy The use of the PD-1 specific monoclonal antibody nivolumab resulted in tumor volume reduction in one fifth of patients with advanced liver cancer

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