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Se and trophoblast physiology Trophoblasts, cells forming the outer layer of the blastocyst, contribute to implantation, placenta development, and oxygen and metabolite exchange between the embryo and the mother, leading to successful fetal development [32]

Statements Author contributions YW, QZ, and XH contributed to the conception and design of the work

BMC Public Health 21 , 1015 (2021)

66 The lncRNAs Linc00210 and lncRNA-CCAL inhibit the activity of CTNNBIP1 and activator protein-2 (AP-2), respectively, and block the binding of CTNNBIP1 and AP-2 to -catenin, enhancing the interaction between -catenin and the TCF/LEF complex

doi:10.1016/j.semarthrit.2016.03.011 52

Females with pre-menstrual flares or polycystic ovary syndrome may benefit from treatment with metformin and hormonal modulators including spironolactone and oral contraceptive pills