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Oxidation of MetHb results in the formation of sulfhemoglobin (SulfHb) along with superoxide anion (O 2 )

PMID: 7007271

Phillips GL, Bernstein SH, Liesveld JL, Abboud CN, Becker MW, Constine LS, Ifthikharuddin JJ, Loughner JE, Milner LA, Vesole DH, Friedberg JW Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

that Sorry if over complicating this

Nitric oxide is an important signaling molecule involved in many biological processes at the cellular level

Inflammatory cytokines associated with underlying disease inhibit erythropoiesis (direct inhibition of progenitors, blunting erythropoietin release or by stimulating secretion of hepcidin)