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High-dose supplementation (400 mg/day) of riboflavin over a time course of three months was found to significantly reduce the frequency, duration and pain score of migraine attacks in both men and women in a meta-analysis of eight RCTs and one intervention study 66

C., Potvin, D., Moyle, G., Soulban, G., Loughrey, H., Marsolais, C., Turner, R., Grinspoon, S

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However, in an untreated autoimmune thyroiditis population, the effect was significant only after 3 months ( Reference Wichman, Bonnema and Hegedus 88 )

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