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10.1016/j.ymthe.2016.11.019 389 YanF.ZhaoQ.LiY.ZhengZ.KongX.ShuC.et al (2022a)

Roderique JD, Josef CS, Newcomb AH, Reynolds PS, Somera LG, Spiess BD

While many of these diseases were once localized to specific geographical regions, recent expansion of the causative agents (ticks, mosquitos, etc.) has resulted in an increased incidence of diseases in areas once considered low-risk

Esculin can inhibit oxidative stress in liver injury, as esculin (10-40 mg/kg) can activate the Nrf2 signaling pathway to increase HO-1 expression levels and decrease the MDA content in lipopolysaccharide (LPS)/D-galactosamine-induced acute liver injury mice (61)

Some of Jerne's thinking at that time is captured by his later close collaborator Ivan Lefkovits: 'Niels realized that Burnet's clonal selection was so clear, convincing and logical that there was little to add to it

Yes, but it must be handled with care and clean tools to avoid damage