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Patients with MDD exhibit KP dysregulation, often marked by an overproduction of quinolinic acid, an N-Methyl-D-aspartic acid receptor (NMDAR) agonist that drives excitotoxicity, alongside reduced production of kynurenic acid, an NMDAR antagonist that protects from excitotoxicity and has anti-inflammatory effects

Peeling could be a sign of dehydration dry lips, but it can also be triggered by lip licking, spicy or citrusy foods, and allergic reactions to lip products

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The ZBP1-MLKL necroptotic pathway, through its interaction with tumor cell-intrinsic STING signaling, has been shown to drive persistent inflammation and enhance radiation-induced antitumor immunity (Yang et al., 2021)

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The GALT relies on signals from a balanced microbiome to maintain immune tolerance and distinguish between harmful and harmless antigens