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Cardiometabolic disease is used as an umbrella term for all the above cases, and severity of cardiometabolic disease refers, in this manuscript, to the progression from single risk factors such as obesity to overt T2D and cardiac phenotype (ischemic heart disease and heart failure)

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This is largely due to the difficulty of distinguishing cell identity feature sets from cell-state markers in transcriptomic data, with classical correlation analyses relying heavily on statistical differences to segregate cell identities

Nat Protoc (2009) 4:4457.10.1038/nprot.2008.211 23 KwonATArenillasDJWorsley HuntRWassermanWW