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Additionally, exploring complementary or alternative compoundssuch as apamin, mast cell degranulating peptide, curcumin, and resveratroleither individually or in combination with melittin could mitigate cytotoxicity while enhancing therapeutic efficacy

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This review systematically describes the multi-target mechanisms of SIRT1 in MASLD pathogenesis through its regulation of critical factors, including peroxisome proliferator-activated receptor gamma coactivator 1-, Forkhead Box O, and nuclear factor kappa-light-chain-enhancer of activated B cells, which govern hepatocyte lipid remodeling, mitochondrial quality control, autophagyendoplasmic reticulum stress balance, and Kupffer cell/T cell polarization

doi: 10.1371/journal.pone.0186934 7 SantosRGMachovsky-CapuskaGEAndradesR

This combination was chosen to enhance dietary compatibility and improve gastrointestinal comfort