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Stress increased depressive-like behavior, evaluated by longer immobility time in the forced swimming test, in addition to altering the expression of microRNAs and genes related to neurotransmission in different brain regions

10.2337/db15-1033 117

many other glycosylation-prone targets have been identified that link nutrient availability with growth signaling 105,106,107,108,109,110 and this branch of research deserves more attention 111

In contrast, cancers with high expression of only one or two enzymes display metabolic flux redirection or environmental dependence, requiring combination strategies targeting transporter bypass pathways or microenvironmental remodeling cascades

Female transgenic mice also showed improvements in working memory, suggesting cognitive benefits of KD in this mouse model [95]

Collectively, these data have identified a biological difference between children who are discordant for konzo and emphasize the role of oxidative stress in neglected motor system diseases, effectively opening new venues for research into potential disease mitigation strategies