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Consumption of NADPH for 2-HG synthesis increases pentose phosphate pathway flux and sensitizes cells to oxidative stress

In vitro experiments demonstrated that NNMT overexpression significantly increased Sirt1 protein expression in primary hepatocytes, while NNMT knockdown led to a notable decrease in Sirt1 protein expression

593,598,599 SIRT3 protects against mitochondrial damage in the kidneys by attenuating oxidative stress, inhibiting inflammation and inducing autophagy through regulation of the AMPK/mTOR pathway

IAF, inner annulus fibrosus

Several testing methods can be employed to accurately measure the vitamin B6 levels in the body

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