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in Denver, Colorado, March 14, 2024

doi: 10.1016/j.psychres.2020.113382

Immune-mediated iron dysregulation: Interferon- (IFN-) downregulates SLC7A11 via the JAK1-2/STAT1 axis, leading to GSH depletion, triggering ferroptosis in RPE cells (107)

By doing so, the present review aims to bridge molecular insights relevant to autoimmune diseases, emphasizing how folate-dependent epigenetic regulation can contribute both to disease-risk stratification and to the development of personalized therapeutic strategies