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In particular, TFEB family members are orphan of a TOS motif and are instead recruited to mTORC1 through a direct interaction with the RagC GTPase ( ON , TFEB is sensitive to any perturbation that would result in a change in the nucleotide to which RagC is bound, such as nutrient withdrawal/replenishment, but would be less affected by the inhibition and activation of the growth factor signaling cascade

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162 Additionally, the meningeal lymphatic system is crucial for A clearance, and its function is impaired with age, leading to cognitive decline