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The reaction rate is influenced by the nucleophilicity of the thiolate, resulting in the enhanced capacity of NAC for reducing disulfide bonds compared to cysteine and GSH (Noszl et al., 2000)

These findings establish innate RNA sensing as an intrinsic driver of hematopoietic stem cell aging and highlight modulation of MDA5-dependent pathways as a potential strategy to mitigate age-related hematopoietic dysfunction

During all stages of atherogenesis, endothelial dysfunction, oxidative stress and inflammation contribute to disease development and progression (Nus and Mallat, 2016)

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Urine acylglycine concentrations were further corrected for renal function and expressed as mmol/mol creatinine (crt)