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As a potent MMP-9 inhibitor, sulforaphane has been shown to reduce MMP-9 expression levels in cerebral ischemia and encephalomyelitis, thereby attenuating neuroinflammation and promoting blood-brain barrier repair [44, 45]

These newly formed vessels have extremely thin walls and lack smooth muscle components, thus hindering proper oxygen delivery and drug transport during tumor treatment

Another protease, ALV003, is further along in development and appears to have greater therapeutic potential

Glutamate receptor-mediated analgesic activity of NAC was first observed in rodent models [74,75] and this same metabotropic glutamate receptor-mediated analgesic effect of NAC was later demonstrated in human volunteers exposed to laser stimuli pain [76]

DNA is also a major target, with ROS causing strand breaks and base modifications such as 8-hydroxydeoxyguanosine (8-OHdG), leading to genomic instability and activation of pro-apoptotic pathways [46]