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The anaesthetics prilocaine and lidocaine along with the herbicide propanil also undergo hydrolysis in humans 11,12,13 and exposure to their amine metabolites has been shown to induce methaemoglobinemia in vitro and in patients 3,13,14

Lactylation in neuropsychiatric disorders Glucose and lactate serve as the principal energy substrates for the nervous system due to the significant energy requirements of the brain