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Crespo et al

The observed increase in antioxidant enzyme activities (e.g., catalase, peroxidase, and ascorbate peroxidase) likely contributed to the synthetic varietys ability to detoxify reactive oxygen species under drought conditions, protecting cellular structures and maintaining physiological processes

Carnivores, with a urine pH of 5.5 to 7.0, will have a greater renal excretion of basic drugs than herbivores, with a urine pH of 7.0 to 8.0

The FXR agonist fexaramine not only restores intestinal FXR activity in mice induced by deoxycholic acid(DCA), but also regulates the abundance of short-chain fatty acid-producing bacteria, thereby alleviating intestinal inflammation [476]

This suggests that in vitro data be used with caution in risk assessment, being mindful that in vitro experiments avoid in vivo pharmacokinetic and metabolic processes

Therefore, it is no surprise that mitochondrial dysfunction emerges as one of the common causes of neurodegeneration in many different diseases, and ALS is no exception