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The literature further indicates that the simultaneous intake of acidsuppressing medications (such as proton pump inhibitors [PPIs] and histamine 2 receptor antagonists [H2RAs]) with metformin increases the risk of vitamin B12 deficiency in individuals with T2D [44-48]

This refers to unplanned pregnancies occurring in women who previously struggled to conceive or who were using oral contraceptives

Nutr Cancer 2010;62(2):190-197

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