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It also activates mitochondrial-mediated apoptosis through downregulation of anti-apoptotic proteins (Bcl-2, survivin) and upregulation of pro-apoptotic markers (Bax, Bid, cytochrome c, and caspases 3, 8, and 9) (Ren et al., 2015

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[] This same report also indicated that TRF has the ability to protect cells from injury by maintaining the sulfhydryl groups found in membrane proteins and through interactions with membrane fatty acid chains