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Role of the polyol pathway in high glucose-induced apoptosis of retinal pericytes and proliferation of endothelial cells

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

The molecular origin for the more selective binding of ether analogues to this target was elucidated by crystallography

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Vitamin E may also play a role in reducing the risk of heart disease (important for women with PCOS).Oxidative stress is a major concern for women who are trying to conceive and have either insulin resistant, PCOS or diabetes