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Additionally, primary hepatocytes were obtained from a single donor, so future studies will investigate inter-individual variation in ITZ toxicity in vitro and in vivo

Cons: Some individuals may be sensitive to bee venom 6

Plain X-ray films and sialography will show the calculus

This, along with the upregulation of multiple mitochondrial genes involved in heme synthesis, OXPHOS assembly and mitochondrial fusion, might be an effort to compensate for the mitochondrial defect caused by the cIII disruption