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Krinsky DL, LaValle JB, Hawkins EB, et al

Group Comparisons at Week 8 : Group 1 (topical and oral placebo) MI: 385.69 94.38 Group 2 (topical GSH, oral placebo) MI: 330.69 87.90 Group 3 (oral GSH, topical placebo) MI: 347.00 81.77 Group 4 (topical and oral GSH) MI: 314.35 70.13 P - values for Group Comparisons : Group 1 vs Group 2: P = 0

Despite significant advancements in improving the specificity of cytokine therapies, further research is needed to focus on targeting downstream signaling pathways or specific receptors to minimize the adverse effects associated with these treatments

Figure 6 4 Discussion Traditionally there has been a strong bias in basic research on circadian rhythms towards the use of male animals in studies with less than 20% of work in this area including female cohorts (27)

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