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Mangion I

NOX is a multisubunit enzyme complex composed of five essential subunits, two of which are localized in the membrane, while three are localized in the cytosol

MRD inhibited SAM-induced m6A methylation and translation of immune checkpoints such as PD-L1 and V-domain Ig suppressor of T cell activation (VISTA) in various mouse tumor models such as colorectal cancer and sarcoma