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doi:10.1186/1471-2261-5-32

Roman G, Demian C, Yousefi-Nooraie R, Love T American journal of health promotion : AJHP

The mitochondrial DNA concentration in the skeletal muscles of healthy subjects also decreases if they perform intense exercise, but because the gene that encodes peroxisome proliferators-activated receptor-coactivator-1a (PGC-1a), which is involved in mitochondrial energy production during high-intensity exercise, is overexpressed in COPD patients, excessive production of active oxygen species as a result of intense exercise may be the reason for the decrease in mitochondrial DNA [33]

Baseline demographic and clinical characteristics of patients with acute ischemic stroke

Restoring lysosomal function, for example, by activating the transcription factor TFEB using compounds like Torin1 or Metformin to upregulate lysosomal gene expression, promotes lysosome biogenesis (130132)