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Lipophilic, nonpolar, and low molecular weight substances such as oxygen, carbon dioxide, and alcohol can pass through the cardiovascular cell membrane and enter the BBB through a cross-cellular pathway[33]

Its gastric stability is remarkable: it survives the stomach's pH of 1-2 without being degraded, opening the possibility of oral administration in certain preclinical protocols

however, there are significant differences between these problems, as shown in Table 1

Standard water-based solutions may struggle to penetrate the scalps lipid barrier effectively

reconstituted solution at 28C for up to 4 weeks

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