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Acta Biomembr

It is a ubiquitous, evolutionarily conserved intracellular defense mechanism, a master regulator of cytoprotective enzymes that regulates redox metabolism, inflammation, bone remodeling, and detoxification in multiple auto-immune diseases like inflammatory bowel disease and asthma 62

66 MahanamaR.BerenjianA.ValtchevP.TalbotA.BiffinR.RegtopH.et al (2011)

[DOI] [PMC free article] [PubMed] [Google Scholar] Bhogal A.A., Broeders T.A.A., Morsinkhof L., Edens M., Nassirpour S., Chang P., Klomp D.W.J., Vinkers C.H., Wijnen J.P

A few amount of this residue may also give higher oxidized forms such as sulphinic and sulfonic derivatives

The effects of NMD on the hypoxia response are neither caused by a general downregulation of HIF-1 activity, nor through HIF-1-dependent regulation of NMD, but instead NMD likely acts in parallel to HIF-1 to co-regulate specific aspects of the hypoxia response