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Second, while in vitro cell models offer high controllability for dissecting signaling pathways, they lack critical multi-organ interactionssuch as those along the gutliver axismaking it difficult to recapitulate the multi-target and systemic regulatory effects of hawthorn under physiological conditions

Inadequate perfusion in areas of rapid cell proliferation creates hypoxia and decreases the supply of nutrients including glucose

The primary cause of alcohol overdose is binge drinking, where a large quantity of alcohol is consumed in a short period

Concerning LC-induced effect on the seminiferous tubule's diameter, it could be said that LC's protective and anti-oxidant role against free radicals reduces the oxidative stress, accelerating spermatogenesis cells' differentiation and increasing sperm release from the seminiferous tubule luminal surface (20)

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