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Biological activity of the endocannabinoid system Once in the body, 9 -THC and CBD exert their effects via the endocannabinoid system (ECS).The identification of the specific binding sites for 9 -THC in the brain [45], complemented by the cloning of the cannabinoid receptor 1 (CB1), that led to the development of the concept of a cannabinoid receptor system given the binding of 9 -THC to CB1 as a partial agonist [46]

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Even in its purest form, nicotine comes with cardiovascular impacts, including an increased heart rate, temporary rises in blood pressure and constriction of blood vessels

Despite the controversies surrounding tobacco and its consumption, its cultivation continues to be an important activity in various countries, generating employment and contributing to the local economy