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Hydroxysafflor yellow A can improve depressive behavior by inhibiting hippocampal inflammation and oxidative stress through regulating HPA axis

An imbalance of the gut microbiota can lead to immune activation and inflammation, particularly through an increase in pro-inflammatory lipopolysaccharides (LPS), which results in increased production of inflammatory cytokines, such as TNF-, IL-1, and IL-6 (218)

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