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Hypothesis: Thanks to a stronger weight loss, CagriSema should lead to a superior reduction of MACE compared to Semaglutide in SELECT (where Semaglutide reduced MACE by 20 %)

Two products with identical percentages can produce vastly different outcomes based on their overall composition

Traditional treatments like NSAIDs and corticosteroids provide temporary relief but come with significant drawbacks

Although the p values were not significant, more cases in the male and female subgroup may be needed to show differences

Site rotation: rotating across a mapped grid prevents scar tissue accumulation and maintains consistent absorption over multi-month cycles

CHALLENGES TO DEVELOPMENT In developing the second-generation amylin-analog cagrilintide there were 2 main barriers: (1) to prevent amylin protein aggregation and (2) to extend the amylin-analogs half-life