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By dosage, the mean changes were: 500 mcg: 127% 750 mcg: 176% (single study) 1,000 mcg: 280% 1,500 mcg: 310% 2000 mcg: 260% 5,000 mcg: 62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways

doi: 10.1002/lary.22490

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Vitamin B12 (cobalamin) is a water-soluble vitamin critical for red blood cell formation, DNA synthesis, neurological function, and energy metabolism

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this percentage drops to 55% for a 100 mcg dose, and decreases to 15% when a 1000 mcg dose is given