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The thioredoxin system acts as a scavenger for ROS, while SOD uses Cu, Zn, and Mn as cofactors to break down superoxide anions into H 2 O 2 and O 2

Plant J 38:473486 Denby KJ, Jason LJ, Murray SL, Last RL (2005) ups1, an Arabidopsis thaliana camalexin accumulation mutant defective in multiple defence signalling pathways

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General guidelines for methodologies on research and evaluation of traditional medicine, WHO-UNO, Geneva, Switzerland, WHO/EDM/TRM/2000.1, 174 32

For influenza virus, the ability of HA stem-targeting nAbs to induce ADCC but their rather weak neutralizing activity compared with nAbs to the HA head domain, which have weak interaction as immune complexes with FcRs but potent neutralizing activity, probably explains the dependence of anti-stem nAbs (but not anti-head nAbs) on Fc-dependent effector functions for protective efficacy 173