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This binding leads to longer retention in individuals with higher body fat

So, its not something new

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Available online at: Summary Keywords cytochrome P450, drug-drug interactions, adverse drug reactions, antibiotics, nicotine, smoking cessation Citation Bellanca CM, Polosa SP, Augello E, Di Benedetto G, Burgaletto C, Cantone AF, Gaudio G, Nunnari G, Campagna D, Nailes JM, Shahbaz H, Tanuwihardja RK, Mohan A, Ceccarelli M, Bernardini R, Marino A and Cantarella G (2025) A scoping review about smoking, smoking cessation and their effects on anti-tuberculosis agents: insights into drug metabolisms, safety, and effectiveness

My drawings and his essays exist together without one being secondary to the other

They're not risk-free (nicotine is addictive), but the harm profile is dramatically different from smoking