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Nuclear receptor coactivator 4 (NCOA4) mediates the selective autophagic degradation of ferritin, a process known as ferritinophagy, which releases Fe + and exacerbates intracellular iron overload ( + out of the cell, thereby preventing iron overload ( 3 The pervasive role of ferroptosis in tumor diseases 3.1 Ferroptosis and cancer cell proliferation Ferroptosis has been recognized as a pivotal process in the pathogenesis and therapeutic response of various cancers

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At these concentrations, Vitamin C can act as a pro-oxidant, generating hydrogen peroxide that selectively targets tumor cells, which often lack protective catalase enzymes (Chen, 2005)

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Conclusion: The paper provides a detailed analysis of quercetin, suggesting its significant role in modulating cell death mechanisms and mitigating liver fibrosis, underscoring its therapeutic potential