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Importance of NE has been demonstrated in a study by Papayannopoulos et al., where pharmacological inhibition of NE activity led to a complete block of NETosis and mice lacking NE also did not form NETs in a pulmonary model of Klebsiella pneumoniae infection [140]

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Therapeutic Applications and Future Potential Diagram illustrating NAD+ metabolism, including biosynthesis, degradation pathways, and related enzymes and functions

Expanding on this work, Yoo et al

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This epidemic infection is out of control, and the widely popularized the current HIV/AIDS pharmaceuticals take good advantage of the concept of pharmaceutical synergism, wherein two different targets in one process are hit simultaneously