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Emodin suppresses cancer growth by regulating the processes of necroptosis, autophagy, ferroptosis and uncoupling Emodin demonstrates anti-cancer activity against prostate, renal, glioma, liver, colon cancers, and melanoma by inducing necroptosis, autophagy, and ferroptosis through various signaling pathways [451, 452]

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CrossRef Overexpression of miR-297b-5p in Mouse Insulin-Secreting Cells Promotes Metformin-Mediated Protection Against Stearic Acid-Induced Senescence by Targeting Igf1r Qingrui Zhao, Shenghan Su, Yuqing Lin, Xuebei Li, Lingfeng Dan, Chunxiao Yang, Chenchen Geng, Romano Regazzi, Xiaohan Li, Yimeng Dong, Changhao Sun, Xia Chu, Huimin Lu Frontiers in Bioscience-Landmark.2023;[Epub] CrossRef Metformin disrupts insulin secretion, causes proapoptotic and oxidative effects in rat pancreatic betacells in vitro Mara M.R