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13 Cryotherapy, the application of cold temperatures, is also a potential nonpharmacologic prevention tool for CIPN

Additionally, dysregulated lipid metabolism, characterized by elevated fatty acid levels and lipid peroxidation, has been linked to vascular dysfunction and endothelial damage (6)

doi: PubMed: 16901483

Consistent with published structural data, AlphaFold2 predicted the association of a conserved surface-exposed hydrophobic cavity on VPS29 (defined by Leu152) with Pro-Leu (PL) motifs from TBC1D5 ( 141 PL 142 ) and VARP ( 713 PL 714 ) and for TBC1D5, the association of an additional 283 Ile-Pro-Phe 285 hydrophobic motif with VPS35 (Supplementary Fig

Therefore, BH4 should not be understood solely as an enzyme cofactor, but should instead be depicted as a cytoprotective pathway that is finely regulated by the interaction of three different metabolic pathways, thus assuring specific intracellular concentrations