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83 The folate cycle uses glycine and tetrahydrofolate (converted from folic acid) and produces intermediates (5,10-methylene-tetrahydrofolate and 5-methylene-tetrahydrofolate) to supply methyl groups for purine synthesis

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75,76 ASOs that employ this mechanism are splicing-switching oligonucleotides, which modulate functional target gene expression by skipping or including exons

Evolution in an ancient detoxification pathway is coupled with a transition to herbivory in the Drosophilidae

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