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For example, kallikrein and prostaglandin E1 have been proven to significantly improve erectile function in diabetic rats, reduce penile fibrosis, and increase blood perfusion, thereby alleviating microvascular complications and addressing diabetes-related reproductive dysfunction [349, 350]

Imlimthan S, Correia A, Figueiredo P, Lintinen K, Balasubramanian V, Airaksinen AJ, Sarparanta M (2020) Systematic in vitro biocompatibility studies of multimodal cellulose nanocrystal and lignin nanoparticles

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4.4 Lipoxygenase Lipoxygenases (LOXs) constitute a family of non-heme iron-containing dioxygenases that catalyze the stereoselective monooxygenation of PUFAs, with their nomenclature typically denoting their positional specificity of oxygen insertion (Kuhn and Thiele, 1999

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In animals, this ancestral timekeeping framework evolved into transcriptiontranslation feedback loops involving core genes like Clock, Bmal1, Per , and Cry , which share homology with ancient microbial photoreceptors and transcription factors (Stanton et al., 2022)