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Quantitative analyses reveal that both cytokine concentration and temporal expression patterns significantly influence subsequent neurodegenerative progression, with chronic low-level inflammation potentially exerting more detrimental effects than acute inflammatory responses due to the cumulative impact of sustained neuronal exposure to inflammatory mediators (36, 37)

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Lee B., Moon K.M., Kim C.Y

[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Huang Y.C., Huang P.R., Lo Y.C., Sun C.W., Pan W.H., Wang S.L., Huang H.B

Thus, natural compensatory mechanisms may develop to a lesser extent in MPTP-treated monkeys

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