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Another amphetamine derivative and serotonin and norepinephrine releaser, 3,4-methylenedioxymethamphetamine (MDMA), also presented marked acute pharmacological tolerance to both subjective and cardiovascular effects (Hysek et al., 2012, 2014)

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LIVER STEATOSIS The first step on the path to liver damage is the accumulation of lipids in hepatocytes leading to steatosis and then, under the influence of factors that have not been fully clarified, to inflammation, fibrosis and eventually cirrhosis

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However, no relationship was noted between BPD and the TRX-1 levels